Radiochemistry Platform

Infrastructures
Research areas
  • Physical Sciences
Contact

Vanessa Gómez Vallejo Email:vgomez@cicbiomagune.es Telephone no.: +34 943 00 53 30

Available for external users?
Yes
Access protocol

Contact with Platform Manager, by email external.services@cicbiomagune.es or check the services here.

Description

The radiochemistry platform includes a radiochemistry lab equipped with 5 hot cells which house automatic-remote controlled synthesis modules (suitable for the preparation of PET and SPECT radiotracers), a shielded laminar flow cabinet and state of the art quality control equipment, including radio-HPLC, radio-GC, radio-TLC and gamma spectrometry. The versatility of the equipments allows the synthesis of a wide range of known PET and SPECT radiotracers, as well as the design of new labelled structures to undertake pharmacokinetic and pharmacodynamic studies. The platform, furthermore, includes a fully equipped lab for radioactive metabolite analysis in blood and tissue samples and a cell culture lab for in vitro studies with radiolabelled ligands.

Services

Radiotracers Catalog:

11C Radiotracers: Acetate, PH11195, Methionine, Choline, DASB, Kendine, PE2I, Raclopride, Harmine, PIB, QNB, Sidenafil, Flumazenil, FLB-457

18F-Radiotracers: F-, FDG, FAP, FLT, FDDNP, FMISO, Altanserin

13N-Radiotrancers: NH3, 4-Pheylazo derivatives

Cyclotron IBA Cyclone 18/9 cyclotron: it has seven targets for the routine production of [18F]F , [18F]F2, [13N]NH4+, [15O]O2, [11C]CO2 and [11C]CH4. A solid target suitable for the production of other positron emitters (e.g. 124I, 89Zr, 45Ti, 64Cu) or direct activation of nanomaterials is also available.

Radiochemistry Production Laboratory:
Once the activity is generated in the cyclotron, it is transferred to the synthesis modules, where the synthesis, purification and formulation are performed; those modules are placed inside the hot cells, made of 75 mm of lead. This area includes a shielded laminar flow cabinet to prepare the doses in aseptic conditions and a hot cell dedicated to 68Ga.

The laboratory is also equipped with state-of-the-art quality control equipment, including radio-HPLCs, radio-TLC, radio-GC, GC-MS and multichannel energy analyzer.

Cell Laboratory
The cell laboratory is equipped with all the necessary equipment to work in a level 1 cell laboratory. Furthermore, a rotating radioimmunoassay equipment (LigandTracer) is available to perform real-time monitoring of protein-cell surface receptors binding studies, among others.

Metabolite Analysis Laboratory In the metabolite analysis laboratory, a radio-HPLC, a gamma counter and several centrifuges are available to be able to run metabolite analysis and dissection, cut and counting studies.

Location

CIC biomaGUNE Parque tecnológico de Gipuzkoa Ed. Pº Miramón 182, 20014, San Sebastián