The Bioengineered Particles laboratory focuses on understanding the interaction of colloidal nanomaterials with the biological matter, such as proteins and cells. Our work is dedicated to the synthesis of highly defined nanoparticle libraries, their physicochemical characterization, and correlation of biological effects to their physicochemical properties. We also develop new methods toward novel methodologies for physicochemical characterization in situ and in complex environments. The main research lines are described below.
- Model libraries in which different physicochemical parameters are varied
- Tuning of nanoparticle surface chemistry by amphiphilic polymers
Particle imaging in cells
- Fluorescence microscopy
- Synchrotron radiation
- Fate of colloids in cells
- Quantification of the protein corona